2010 Opponents
| Wk | Date | Game | Stadium | Time (ET) |
| 1 | Sep 12 | IND @ HOU | Reliant Stadium | 1:00 PM |
| 2 | Sep 19 | HOU @ WAS | FedEx Field | 4:15 PM |
| 3 | Sep 26 | DAL @ HOU | Reliant Stadium | 1:00 PM |
| 4 | Oct 03 | HOU @ OAK | Oakland Coliseum | 4:05 PM |
| 5 | Oct 10 | NYG @ HOU | Reliant Stadium | 1:00 PM |
| 6 | Oct 17 | KC @ HOU | Reliant Stadium | 1:00 PM |
| 7 | Bye | |||
| 8 | Nov 01 | HOU @ IND | Lucas Oil Stadium | 8:30 PM |
| 9 | Nov 07 | SD @ HOU | Reliant Stadium | 1:00 PM |
| 10 | Nov 14 | HOU @ JAC | Jacksonville Municipal Stadium | 1:00 PM |
| 11 | Nov 21 | HOU @ NYJ | New Meadowlands Stadium | 1:00 PM |
| 12 | Nov 28 | TEN @ HOU | Reliant Stadium | 1:00 PM |
| 13 | Dec 02 | HOU @ PHI | Lincoln Financial Field | 8:20 PM |
| 14 | Dec 13 | BAL @ HOU | Reliant Stadium | 8:30 PM |
| 15 | Dec 19 | HOU @ TEN | LP Field | 1:00 PM |
| 16 | Dec 26 | HOU @ DEN | Invesco Field at Mile High | 4:05 PM |
| 17 | Jan 02 | JAC @ HOU | Reliant Stadium | 1:00 PM |
